The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide

Irving H. Zucker; Harold D. Schultz; Yi Fan Li; Yu Wang; Wei Wang; Kaushik P. Patel

doi:10.1016/j.pbiomolbio.2003.11.010

The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide

Irving H. Zucker, Harold D. Schultz, Yi Fan Li, Yu Wang, Wei Wang, Kaushik P. Patel

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

Abstract

The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

Original language	English (US)
Pages (from-to)	217-232
Number of pages	16
Journal	Progress in Biophysics and Molecular Biology
Volume	84
Issue number	2-3
DOIs	https://doi.org/10.1016/j.pbiomolbio.2003.11.010
State	Published - 2004

Keywords

Baroreflex
Chronic heart failure
Medulla
Neurohumoral regulation
Renal nerve activity

ASJC Scopus subject areas

Biophysics
Molecular Biology

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10.1016/j.pbiomolbio.2003.11.010

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title = "The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide",

abstract = "The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.",

keywords = "Baroreflex, Chronic heart failure, Medulla, Neurohumoral regulation, Renal nerve activity",

author = "Zucker, {Irving H.} and Schultz, {Harold D.} and Li, {Yi Fan} and Yu Wang and Wei Wang and Patel, {Kaushik P.}",

note = "Funding Information: The authors acknowledge the generous support of several agencies including the National Institutes of Health and the American Heart Association for funding many of the studies summarized in this review. In addition, we thank Ms. Johnnie F. Hackley and, Mrs. Pamela Curry for their outstanding technical support.",

year = "2004",

doi = "10.1016/j.pbiomolbio.2003.11.010",

language = "English (US)",

volume = "84",

pages = "217--232",

journal = "Progress in Biophysics and Molecular Biology",

issn = "0079-6107",

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T2 - The roles of angiotensin II and nitric oxide

AU - Zucker, Irving H.

AU - Schultz, Harold D.

AU - Li, Yi Fan

AU - Wang, Yu

AU - Wang, Wei

AU - Patel, Kaushik P.

N1 - Funding Information: The authors acknowledge the generous support of several agencies including the National Institutes of Health and the American Heart Association for funding many of the studies summarized in this review. In addition, we thank Ms. Johnnie F. Hackley and, Mrs. Pamela Curry for their outstanding technical support.

PY - 2004

Y1 - 2004

N2 - The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

AB - The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.

KW - Baroreflex

KW - Chronic heart failure

KW - Medulla

KW - Neurohumoral regulation

KW - Renal nerve activity

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JO - Progress in Biophysics and Molecular Biology

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IS - 2-3

ER -

The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide

Abstract

Keywords

ASJC Scopus subject areas

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