TY - JOUR
T1 - The oxazolomycins
T2 - a structurally novel class of bioactive compounds.
AU - Moloney, Mark G.
AU - Trippier, Paul C.
AU - Yaqoob, Muhammad
AU - Wang, Zhaoyang
PY - 2004/10
Y1 - 2004/10
N2 - Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.
AB - Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.
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U2 - 10.2174/1570163043334974
DO - 10.2174/1570163043334974
M3 - Article
C2 - 16472256
AN - SCOPUS:33645084821
SN - 1570-1638
VL - 1
SP - 181
EP - 199
JO - Current drug discovery technologies
JF - Current drug discovery technologies
IS - 3
ER -