The oxazolomycins: a structurally novel class of bioactive compounds.

Mark G. Moloney, Paul C. Trippier, Muhammad Yaqoob, Zhaoyang Wang

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.

Original languageEnglish (US)
Pages (from-to)181-199
Number of pages19
JournalCurrent drug discovery technologies
Issue number3
StatePublished - Oct 2004
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery


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