The pathogenesis of bladder cancer

G. H. Friedell, J. B. Jacobs, G. K. Nagy, S. M. Cohen

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Carcinoma of the urinary bladder appears to arise, in at least some cases, from carcinoma in situ developing in a field of atypical epithelial proliferaton. There is both a spatial and temporal relation between invasive and in situ bladder cancer, although the exact relation between the noninvasive flat and papillary types of tumors is not known. Preneoplastic bladder lesions are defined as irreversible, although not necessarily progressive, and an experimental animal model of the disease has been developed. The appearance of pleomorphic microvilli on the luminal surface of epithelial cells of the urinary bladders of Fischer rats is correlated with the irreversibility of hyperplastic epithelial lesions induced by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) to test animals. This alteration can be visualized by scanning electron microscopy of cytologic and histologic preparations.

Original languageEnglish (US)
Pages (from-to)431-442
Number of pages12
JournalAmerican Journal of Pathology
Issue number2
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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