TY - JOUR
T1 - The persistence of DNA damage in the pancreas of Syrian golden hamsters treated with N-nitrosobis(2-oxopropyl)amine
AU - Lawson, T.
AU - Hines, L.
AU - Helgeson, S.
AU - Pour, P.
N1 - Funding Information:
*Supported by Grant 2 R26 CA 20198-04 from the Division of Cancer Cause and Prevention of the National Cancer Institute, National Institutes of Health. Abbreviations: .BOP, N-nitrosobis(2-oxopropyl)amine; DABA, 3,5-diaminobenzoic acid.
PY - 1982/2
Y1 - 1982/2
N2 - DNA damage was estimated in the liver, pancreas and salivary gland of Syrian hamsters given N-nitrosobis(2-oxopropyl)amine (BOP) by alkaline sucrose gradient centrifugation. A single BOP dose (10 mg/kg) produced in all 3 tissues extensive DNA damage that was largely repaired in the salivary gland by 4 weeks, while in the liver and pancreas, some DNA damage persisted until 4 weeks. When higher BOP doses (20 and 40 mg/kg) were used, considerable DNA damage was still evident in the pancreas, but not in the liver at 6 weeks. Greater damage persisted in hamsters given 40 mg/kg, compared with those administered 20 mg/kg.
AB - DNA damage was estimated in the liver, pancreas and salivary gland of Syrian hamsters given N-nitrosobis(2-oxopropyl)amine (BOP) by alkaline sucrose gradient centrifugation. A single BOP dose (10 mg/kg) produced in all 3 tissues extensive DNA damage that was largely repaired in the salivary gland by 4 weeks, while in the liver and pancreas, some DNA damage persisted until 4 weeks. When higher BOP doses (20 and 40 mg/kg) were used, considerable DNA damage was still evident in the pancreas, but not in the liver at 6 weeks. Greater damage persisted in hamsters given 40 mg/kg, compared with those administered 20 mg/kg.
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U2 - 10.1016/0009-2797(82)90061-8
DO - 10.1016/0009-2797(82)90061-8
M3 - Article
C2 - 7060214
AN - SCOPUS:0020048572
SN - 0009-2797
VL - 38
SP - 317
EP - 323
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 3
ER -