The pharmacokinetics of ibuprofen after burn injury

J. B. Cone, B. H. Wallace, K. M. Olsen, F. T. Caldwell, B. J. Gurley, P. J. Bond

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Ibuprofen is an effective antipyretic in the postburn period and produces associated decrements in the hypermetabolic response. Burn injury is capable of altering the kinetics of many drugs, making the predictable use of agents such as ibuprofen difficult. Ten patients with serious burns were studied after the administration of 10 mg/kg ibuprofen suspension. The half-life varied from 1.4 to 5.1 hours, depending on the site of administration and/or the presence of solid food. The reported half-life for ibuprofen suspension is 1.8 to 2 hours. Burn size did not alter ibuprofen half-life or area under the time-concentration curve. Maximum ibuprofen concentration varied greatly, depending on route of administration. Time to maximal temperature reduction was between 2 and 3 hours after drug administration. Although the precise level of ibuprofen needed for cyclooxygenase inhibition is unknown, enterai administration results in levels below the targeted 10 to 20 mcg/ml for much of the traditional 6-hour dosing interval. Future studies with ibuprofen in the burn population must standardize more than just total dose.

Original languageEnglish (US)
Pages (from-to)666-669
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume14
Issue number6
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

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    Cone, J. B., Wallace, B. H., Olsen, K. M., Caldwell, F. T., Gurley, B. J., & Bond, P. J. (1993). The pharmacokinetics of ibuprofen after burn injury. Journal of Burn Care and Rehabilitation, 14(6), 666-669. https://doi.org/10.1097/00004630-199311000-00012