The Pharmacology and Clinical Use of Methotrexate

Jacques Jolivet, Kenneth H. Cowan, Gregory A. Curt, Neil J. Clendeninn, Bruce A. Chabner

Research output: Contribution to journalReview articlepeer-review

663 Scopus citations


METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular.

Original languageEnglish (US)
Pages (from-to)1094-1104
Number of pages11
JournalNew England Journal of Medicine
Issue number18
StatePublished - Nov 3 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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