TY - JOUR
T1 - The Pharmacology and Clinical Use of Methotrexate
AU - Jolivet, Jacques
AU - Cowan, Kenneth H.
AU - Curt, Gregory A.
AU - Clendeninn, Neil J.
AU - Chabner, Bruce A.
PY - 1983/11/3
Y1 - 1983/11/3
N2 - METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular.
AB - METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular.
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U2 - 10.1056/NEJM198311033091805
DO - 10.1056/NEJM198311033091805
M3 - Review article
C2 - 6353235
AN - SCOPUS:0020554087
VL - 309
SP - 1094
EP - 1104
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 18
ER -