The philadelphia chromosome in acute leukemia

Clara D. Bloomfield, Leanna L. Lindquist, Richard D. Brunning, Jorge J. Yunis, Peter F. Coccia

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The cytogenetics, cytology and cytochemistry, clinical findings, therapeutic response and survival of patients presenting with acute leukemia and the Philadelphia chromosome (Ph1) are briefly reviewed based upon a survey of the world literature and 16 cases seen at the University of Minnesota during the last 10 years. Details regarding the 16 cases from the University of Minnesota series are presented and two appendices listing the majority of reports of Ph1 + acute leukemia are included. Comparison of adults with Ph1 + and Ph1 - acute leukemia demonstrate important clinical, therapeutic and prognostic differences. In general, patients with Ph1 + acute leukemia respond less well to treatment and survive significantly shorter periods of time. Since the presence of the Philadelphia chromosome in acute leukemia has therapeutic and prognostic significance, marrow chromosome studies should be performed in adults presenting with acute leukemia, especially acute lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalVirchows Archiv B Cell Pathology
Volume29
Issue number1
DOIs
StatePublished - Dec 1978

Keywords

  • Acute lymphocytic leukemia
  • Acute non-lymphocytic leukemia
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'The philadelphia chromosome in acute leukemia'. Together they form a unique fingerprint.

  • Cite this

    Bloomfield, C. D., Lindquist, L. L., Brunning, R. D., Yunis, J. J., & Coccia, P. F. (1978). The philadelphia chromosome in acute leukemia. Virchows Archiv B Cell Pathology, 29(1), 81-91. https://doi.org/10.1007/BF02899340