The Phycodnaviridae: The story of how tiny giants rule the world

W. H. Wilson, James L. Van Etten, M. J. Allen

Research output: Chapter in Book/Report/Conference proceedingChapter

123 Scopus citations

Abstract

The family Phycodnaviridae encompasses a diverse and rapidly expanding collection of large icosahedral, dsDNA viruses that infect algae. These lytic and lysogenic viruses have genomes ranging from 160 to 560 kb. The family consists of six genera based initially on host range and supported by sequence comparisons. The family is monophyletic with branches for each genus, but the phycodnaviruses have evolutionary roots that connect them with several other families of large DNA viruses, referred to as the nucleocytoplasmic large DNA viruses (NCLDV). The phycodnaviruses have diverse genome structures, some with large regions of noncoding sequence and others with regions of ssDNA. The genomes of members in three genera in the Phycodnaviridae have been sequenced. The genome analyses have revealed more than 1000 unique genes, with only 14 homologous genes in common among the three genera of phycodnaviruses sequenced to date. Thus, their gene diversity far exceeds the number of so-called core genes. Not much is known about the replication of these viruses, but the consequences of these infections on phytoplankton have global affects, including influencing geochemical cycling and weather patterns.

Original languageEnglish (US)
Title of host publicationLesser Known Large dsDNA Viruses
EditorsJames Etten
Pages1-42
Number of pages42
DOIs
StatePublished - Jan 21 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume328
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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    Wilson, W. H., Van Etten, J. L., & Allen, M. J. (2009). The Phycodnaviridae: The story of how tiny giants rule the world. In J. Etten (Ed.), Lesser Known Large dsDNA Viruses (pp. 1-42). (Current Topics in Microbiology and Immunology; Vol. 328). https://doi.org/10.1007/978-3-540-68618-7-1