The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: A target for PI-3 kinase inhibitor intervention

Medicine & Life Sciences

• SF 1126 100%
• Survivin 54%
• Neuroblastoma 45%
• Phosphatidylinositol 3-Kinases 45%
• Insulin-Like Growth Factor I 13%
• Doxorubicin 12%
• Apoptosis 7%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 7%
• Anthracyclines 7%
• Prodrugs 7%
• Tumor Cell Line 6%
• Actin Cytoskeleton 6%
• Integrins 6%
• Heterografts 5%
• Patient Selection 5%
• Signal Transduction 5%
• Up-Regulation 4%
• Water 4%
• Cell Proliferation 4%
• Neoplasms 4%
• Neoplasm Metastasis 4%
• Cell Line 3%
• Drug Therapy 3%
• Growth 3%
• In Vitro Techniques 2%
• Therapeutics 2%

Chemical Compounds

• Phosphatidylinositol 3 Kinase Inhibitor 78%
• Doxorubicin 47%
• LY294002 41%
• Anthracycline 30%
• Prodrug 24%
• Antitumor 21%
• Water Soluble 17%
• Block Like Crystal 15%