The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

Mahmoud Hasan; Shahrzad Latifi; Cyril J.F. Kahn; Ali Tamayol; Rouhollah Habibey; Elodie Passeri; Michel Linder; Elmira Arab-Tehrany

doi:10.3390/md16070218

The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

Mahmoud Hasan, Shahrzad Latifi, Cyril J.F. Kahn, Ali Tamayol, Rouhollah Habibey, Elodie Passeri, Michel Linder, Elmira Arab-Tehrany

Mechanical & Materials Engineering

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

Original language	English (US)
Article number	218
Journal	Marine Drugs
Volume	16
Issue number	7
DOIs	https://doi.org/10.3390/md16070218
State	Published - Jul 2018

Keywords

Curcumin
Nanoliposome
Polar lipid
Primary cortical neurons
Transfer

ASJC Scopus subject areas

Drug Discovery

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10.3390/md16070218

Cite this

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abstract = "Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin{\textquoteright}s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.",

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AU - Tamayol, Ali

AU - Habibey, Rouhollah

AU - Passeri, Elodie

AU - Linder, Michel

AU - Arab-Tehrany, Elmira

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AB - Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

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The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

Abstract

Keywords

ASJC Scopus subject areas

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