The potential of food protein-derived anti-inflammatory peptides against various chronic inflammatory diseases

Kaustav Majumder, Yoshinori Mine, Jianping Wu

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Inflammation is considered as one of the major causes for the initiation of various chronic diseases such as asthma, cancer, cardiovascular disease, diabetes, obesity, inflammatory bowel disease, osteoporosis and neurological diseases like Parkinson's disease. Increasing scientific evidence has delineated that inflammatory markers such as TNF-α, IL-1, IL-6, IL-8 and CRP and different transcription factors such as NF-κB and STAT are the major key factors that regulate these inflammatory diseases. Food protein-derived bioactive peptides have been shown to exhibit anti-inflammatory activity by inhibiting or reducing the expression of these inflammatory biomarkers and/or by modulating the activity of these transcription factors. This review aims to discuss various molecular targets and underlying mechanisms of food protein-derived anti-inflammatory peptides and to explore their potential against various chronic inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)2303-2311
Number of pages9
JournalJournal of the Science of Food and Agriculture
Volume96
Issue number7
DOIs
StatePublished - May 1 2016

Keywords

  • Atherosclerosis
  • Bioactive peptides
  • Chronic disease
  • Food protein
  • Inflammation
  • Insulin resistance
  • Obesity, anti-inflammatory activity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Agronomy and Crop Science
  • Nutrition and Dietetics

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