Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Nov 1967|
ASJC Scopus subject areas
- Cancer Research