The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide

E. Ertürk; J. M. Price; J. Emory Morris; S. Cohen; Ronnie Sue Leith; A. J. Crovetti

The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide

E. Ertürk, J. M. Price, J. Emory Morris, S. Cohen, Ronnie Sue Leith, A. J. Crovetti

Research output: Contribution to journal › Article › peer-review

Abstract

Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.

Original language	English (US)
Pages (from-to)	1998-2002
Number of pages	5
Journal	Cancer Research
Volume	27
State	Published - Nov 1967
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide",

abstract = "Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.",

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AU - Cohen, S.

AU - Leith, Ronnie Sue

AU - Crovetti, A. J.

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AB - Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.

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The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide

Abstract

ASJC Scopus subject areas

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