The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide

E. Ertürk, J. M. Price, J. Emory Morris, S. Cohen, Ronnie Sue Leith, A. J. Crovetti

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

Thirty female Sprague-Dawley rats were fed 0.188% of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for 46 weeks. Twenty-nine of the rats lived 34 weeks or more and all of these animals developed gross bladder carcinomas. Three rats developed carcinomas of the renal pelvis which invaded the kidney. There were 15 animals with 1 or more gross mammary tumors, all of which were classified as benign adenoma, fibroadenoma, or adenofibroma. This is the first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.

Original languageEnglish (US)
Pages (from-to)1998-2002
Number of pages5
JournalCancer Research
Volume27
StatePublished - Nov 1967

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ertürk, E., Price, J. M., Morris, J. E., Cohen, S., Leith, R. S., & Crovetti, A. J. (1967). The Production of Carcinoma of the Urinary Bladder in Rats by Feeding N-[4-(5-Nitro-2-furyl)-thiazolyl]formamide. Cancer Research, 27, 1998-2002.