@article{afdec1746d384390af46d4b53bb43463,
title = "The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma",
abstract = "We used gene expression profiling to establish a molecular diagnosis of mantle cell lymphoma (MCL), to elucidate its pathogenesis, and to predict the length of survival of these patients. An MCL gene expression signature defined a large subset of MCLs that expressed cyclin D1 and a novel subset that lacked cyclin D1 expression. A precise measurement of tumor cell proliferation, provided by the expression of proliferation signature genes, identified patient subsets that differed by more than 5 years in median survival. Differences in cyclin D1 mRNA abundance synergized with INK4a/ARF locus deletions to dictate tumor proliferation rate and survival. We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.",
author = "Andreas Rosenwald and George Wright and Adrian Wiestner and Chan, {Wing C.} and Connors, {Joseph M.} and Elias Campo and Gascoyne, {Randy D.} and Grogan, {Thomas M.} and Muller-Hermelink, {H. Konrad} and Smeland, {Erlend B.} and Michael Chiorazzi and Giltnane, {Jena M.} and Hurt, {Elaine M.} and Hong Zhao and Lauren Averett and Sarah Henrickson and Liming Yang and John Powell and Wilson, {Wyndham H.} and Jaffe, {Elaine S.} and Richard Simon and Klausner, {Richard D.} and Emilio Montserrat and Francesc Bosch and Greiner, {Timothy C.} and Weisenburger, {Dennis D.} and Sanger, {Warren G.} and Dave, {Bhavana J.} and Lynch, {James C.} and Julie Vose and Armitage, {James O.} and Fisher, {Richard I.} and Miller, {Thomas P.} and Michael LeBlanc and German Ott and Stein Kvaloy and Harald Holte and Jan Delabie and Staudt, {Louis M.}",
note = "Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2003",
month = feb,
doi = "10.1016/S1535-6108(03)00028-X",
language = "English (US)",
volume = "3",
pages = "185--197",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}