The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver

Terence A. Lawson; Allan W. Pound

doi:10.1016/0014-2964(73)90133-3

The prolonged binding of ethyl carbamate-(¹⁴C) to DNA in regenerating and intact mouse liver

Terence A. Lawson, Allan W. Pound

Eppley Institute for Cancer Research

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The binding of ethyl carbamate-(1-¹⁴C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.

Original language	English (US)
Pages (from-to)	491-496
Number of pages	6
Journal	European Journal of Cancer (1965)
Volume	9
Issue number	7
DOIs	https://doi.org/10.1016/0014-2964(73)90133-3
State	Published - Jul 1973

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General Medicine

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title = "The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver",

abstract = "The binding of ethyl carbamate-(1-14C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.",

author = "Lawson, {Terence A.} and Pound, {Allan W.}",

note = "Funding Information: Accepted 20 April 1973. *The work was generously supported by the Queens-land Cancer Fund.",

year = "1973",

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doi = "10.1016/0014-2964(73)90133-3",

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T1 - The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver

AU - Lawson, Terence A.

AU - Pound, Allan W.

N1 - Funding Information: Accepted 20 April 1973. *The work was generously supported by the Queens-land Cancer Fund.

PY - 1973/7

Y1 - 1973/7

N2 - The binding of ethyl carbamate-(1-14C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.

AB - The binding of ethyl carbamate-(1-14C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.

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The prolonged binding of ethyl carbamate-(¹⁴C) to DNA in regenerating and intact mouse liver

Abstract

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