The prolonged binding of ethyl carbamate-(14C) to DNA in regenerating and intact mouse liver

Terence A. Lawson, Allan W. Pound

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The binding of ethyl carbamate-(1-14C), or a metabolite, to mouse liver DNA persisted longer if it was given to partially-hepatectomised mice compared with intact mice. Chromatographic examination of acid hydrolysates of the liver DNA from the partially hepatectomized mice showed that the radioactivity associated with the DNA was not present as a result of incorporation into the bases during DNA biosynthesis. Ethyl carbamate produced a greater inhibition of DNA turnover in the liver when given to partially-hepatectomized mice compared with intact mice.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume9
Issue number7
DOIs
StatePublished - Jul 1973

ASJC Scopus subject areas

  • Medicine(all)

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