The pseudorabies virus R2 non-neuroinvasive vaccine: A proof-of-concept study in pigs

Gary E. Pickard, Bruce Brodersen, Patricia J. Sollars, Gregory A. Smith

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Neurotropic alpha-herpesviruses that infect mammals establish life-long latent infections in the peripheral nervous system after initial infection of exposed mucosal tissues. The neuroinvasive properties can lead to severe complications both with clinical and veterinary alpha-herpesviruses, and vaccines are often unavailable or provide limited protection. Here we assess the properties and efficacy of an R2 vaccine derived from the alpha-herpesvirus, pseudorabies virus (PRV), in pigs. We demonstrate that the PRV R2 vaccine does not invade the porcine peripheral nervous system within the limits of detection. Furthermore, after a single intranasal vaccination, R2 conferred protection to pigs subsequently challenged with a virulent PRV field strain (NIA-3). These findings support that the R2 vaccine design is non-neuroinvasive and is an effective vaccine in the context of a natural host.

Original languageEnglish (US)
Pages (from-to)4524-4528
Number of pages5
JournalVaccine
Volume38
Issue number29
DOIs
StatePublished - Jun 15 2020

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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