The Rho family of small GTPases: Crucial regulators of skeletal myogenesis

B. A. Bryan, D. Li, X. Wu, M. Liu

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

The Rho family of small GTPases is involved in a diverse array of cellular processes, including regulation of the actin cytoskeleton, cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity. Recent findings have implicated the Rho proteins as key regulators of the skeletal myogenic program; however, much controversy presently exists as to the precise role of these proteins in this process. This review examines the present controversial findings pertaining to the Rho family's regulation of skeletal myogenesis and extrapolates from both other differentiation systems and recently published data the possible mechanisms by which these proteins function in the myogenic cascade.

Original languageEnglish (US)
Pages (from-to)1547-1555
Number of pages9
JournalCellular and Molecular Life Sciences
Volume62
Issue number14
DOIs
StatePublished - Jul 2005

Keywords

  • Cdc42
  • GTPases
  • Myogenesis
  • Rac
  • Rho
  • Skeletal myogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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