The road to tolerance: Renal transplant tolerance induction in nonhuman primate studies and clinical trials

Eric A. Elster, Douglas A. Hale, Roslyn B. Mannon, Linda C. Cendales, S. John Swanson, Allan D. Kirk

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Organ transplantation has become a standard life-saving therapy for many causes of end stage organ failure. Although valuable, it remains hampered by the requirement for, and complications of, immunosuppression to prevent immune rejection of the transplanted organ. It is now clear that rejection can be avoided in some experimental systems without a requirement of immunosuppressive medication, and these experimental concepts are now making their way into the clinic in the form of early transplantation tolerance trials. This manuscript will discuss the most promising techniques for tolerance induction, namely, costimulation blockade, lymphocyte depletion, and mixed chimerism. Seminal preclinical studies will be cited and the results of initial clinical trials will be reviewed. The data to date indicate that while tolerance remains elusive, immunosuppression minimization is a feasible near-term alternative.

Original languageEnglish (US)
Pages (from-to)87-99
Number of pages13
JournalTransplant Immunology
Volume13
Issue number2
DOIs
StatePublished - 2004

Keywords

  • Costimulation blockade
  • Lymphocyte depletion
  • Mixed chimerism
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

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