Abstract
Previously (Liu et al., Cancer Res., 56: 3371-3379, 1996), we isolated a novel serine protease-like gene - Normal Epithelial Cell Specific-1 (NES1) - that is expressed in normal mammary epithelial cells but is down-regulated in most breast cancer cell lines. Here, we demonstrate that stable expression of NES1 in the NES1-negative MDA-MB-231 breast cancer cell line suppressed the oncogenicity as revealed by inhibition of the anchorage-independent growth and tumor formation in nude mice. Fluorescence in situ hybridization localized the NES1 gene to chromosome 19q13.3, a region that contains genes for related proteases (including the prostate-specific antigen) and is rearranged in human cancers. Similar to breast cancer cell lines, prostate cancer cell lines also lacked NES1 mRNA and protein expression. Together, these results strongly suggest a tumor-suppressor role for NES1 in breast and prostate cancer.
Original language | English (US) |
---|---|
Pages (from-to) | 4782-4786 |
Number of pages | 5 |
Journal | Cancer Research |
Volume | 58 |
Issue number | 21 |
State | Published - Nov 1 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research