The role for NES1 serine protease as a novel tumor suppressor

Jaya Goyal, Karen M. Smith, Janet M. Cowan, David E. Wazer, Sam W. Lee, Vimla Band

Research output: Contribution to journalArticlepeer-review

160 Scopus citations


Previously (Liu et al., Cancer Res., 56: 3371-3379, 1996), we isolated a novel serine protease-like gene - Normal Epithelial Cell Specific-1 (NES1) - that is expressed in normal mammary epithelial cells but is down-regulated in most breast cancer cell lines. Here, we demonstrate that stable expression of NES1 in the NES1-negative MDA-MB-231 breast cancer cell line suppressed the oncogenicity as revealed by inhibition of the anchorage-independent growth and tumor formation in nude mice. Fluorescence in situ hybridization localized the NES1 gene to chromosome 19q13.3, a region that contains genes for related proteases (including the prostate-specific antigen) and is rearranged in human cancers. Similar to breast cancer cell lines, prostate cancer cell lines also lacked NES1 mRNA and protein expression. Together, these results strongly suggest a tumor-suppressor role for NES1 in breast and prostate cancer.

Original languageEnglish (US)
Pages (from-to)4782-4786
Number of pages5
JournalCancer Research
Issue number21
StatePublished - Nov 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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