The role of αA-crystallin in experimental autoimmune uveitis

L. Wang, L. Zhang, Z. F. Wang, Z. X. Huang, X. Hu, L. Gong, X. Tang, F. Liu, Z. Luo, W. Ji, W. F. Hu, Z. Woodward, J. Zhu, Y. Z. Liu, Q. D. Nguyen, D. W C Li

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.

Original languageEnglish (US)
Pages (from-to)558-564
Number of pages7
JournalCurrent Molecular Medicine
Volume15
Issue number6
DOIs
StatePublished - Aug 1 2015

Keywords

  • Experimental autoimmune uveitis
  • Gene therapy
  • Uveitis
  • αA-crystallin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Wang, L., Zhang, L., Wang, Z. F., Huang, Z. X., Hu, X., Gong, L., Tang, X., Liu, F., Luo, Z., Ji, W., Hu, W. F., Woodward, Z., Zhu, J., Liu, Y. Z., Nguyen, Q. D., & Li, D. W. C. (2015). The role of αA-crystallin in experimental autoimmune uveitis. Current Molecular Medicine, 15(6), 558-564. https://doi.org/10.2174/1566524015666150731101146