Abstract
The low-grade lymphomas have been referred to as indolent due to their long natural histories relative to the more aggressive lymphomas. The low-grade lymphomas are frequently exquisitely sensitive to a variety of chemotherapeutic agents as well as radiotherapy. Recent attention has focused on the use of high-dose chemotherapy and autologous hematopoietic stem cell transplantation for the treatment of patients with low-grade lymphoma. In view of the incurability of advanced stage low grade lymphomas with conventional chemotherapy or radiotherapy, the use of high-dose chemotherapy and hematopoietic stem cell transplantation in an attempt to overcome chemotherapy resistance and irradiate the malignant clone has been tested in clinical trials. A clinical question that remains unanswered is the effect and necessity of purging in transplantation for low-grade non-Hodgkin’s lymphomas (NHL). Fifteen of 60 patients undergoing transplantation for NHL had polymerase chain reaction-positive bone marrow prior to antibody purging.
| Original language | English (US) |
|---|---|
| Title of host publication | Autologous Stem Cell Transplantation |
| Subtitle of host publication | Biological and Clinical Results in Malignancies |
| Publisher | Taylor and Francis |
| Pages | 321-328 |
| Number of pages | 8 |
| ISBN (Electronic) | 9781000102826 |
| DOIs | |
| State | Published - Jan 1 2020 |
ASJC Scopus subject areas
- General Social Sciences