The role of autografting in low-grade lymphoma

J. M. Vose, Philip Jay Bierman, J. O. Armitage

Research output: Chapter in Book/Report/Conference proceedingChapter


The low-grade lymphomas have been referred to as indolent due to their long natural histories relative to the more aggressive lymphomas. The low-grade lymphomas are frequently exquisitely sensitive to a variety of chemotherapeutic agents as well as radiotherapy. Recent attention has focused on the use of high-dose chemotherapy and autologous hematopoietic stem cell transplantation for the treatment of patients with low-grade lymphoma. In view of the incurability of advanced stage low grade lymphomas with conventional chemotherapy or radiotherapy, the use of high-dose chemotherapy and hematopoietic stem cell transplantation in an attempt to overcome chemotherapy resistance and irradiate the malignant clone has been tested in clinical trials. A clinical question that remains unanswered is the effect and necessity of purging in transplantation for low-grade non-Hodgkin’s lymphomas (NHL). Fifteen of 60 patients undergoing transplantation for NHL had polymerase chain reaction-positive bone marrow prior to antibody purging.

Original languageEnglish (US)
Title of host publicationAutologous Stem Cell Transplantation
Subtitle of host publicationBiological and Clinical Results in Malignancies
PublisherTaylor and Francis
Number of pages8
ISBN (Electronic)9781000102826
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Social Sciences(all)


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