The role of biologic agents in the management of non-infectious uveitis

Jangwon Heo, Yasir J. Sepah, Jithin Yohannan, Morgan Renner, Abeer Akhtar, Anthony Gregory, Mathew Shulman, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Introduction: Uveitis is an intriguing group of disorders characterized by inflammation of the uveal tract. Due to the potential grave consequences of the disease process, it is important to assess the various therapeutic options available for treating uveitis, and their outcomes. Areas covered: This review discusses the use of conventional agents in the management of uveitis, including discussion of the molecular and clinical properties of corticosteroids, antimetabolites, calcineurin inhibitors and alkylating agents and their side effects. In addition, it also discusses the molecular and clinical properties of novel biologic agents and their side effects. Moreover, recommendations as to when biologic agents should be employed are also discussed. Expert opinion: We recommend that in general (except in selected cases of Adamantiades- Behçet's disease) biologics should not be used as a first-line therapy for uveitis due to inconvenience, high cost, and potential immunosuppressive effects. However, many biologics are potent in inducing drug-free remission of uveitis and may be employed to manage recurrent diseases or diseases not responsive to conventional agents.

Original languageEnglish (US)
Pages (from-to)995-1008
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume12
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • biologics
  • intermediate
  • panuveitis
  • posterior

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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    Heo, J., Sepah, Y. J., Yohannan, J., Renner, M., Akhtar, A., Gregory, A., Shulman, M., Do, D. V., & Nguyen, Q. D. (2012). The role of biologic agents in the management of non-infectious uveitis. Expert Opinion on Biological Therapy, 12(8), 995-1008. https://doi.org/10.1517/14712598.2012.688021