The Role of Cell Proliferation in the Etiology of Neoplasia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Cancer is due to multiple genetic errors in a single stem cell fixed permanently during replication, produced either by directly damaging DNA or by increasing DNA replications. Synergies occur when both processes are produced. Cell proliferation can be increased by increasing cell births (direct mitogenicity or cytotoxicity and regeneration) or decreasing cell deaths (inhibit apoptosis or differentiation). Screening for these effects provides a rational basis for mode of action analysis and relevance of model findings to human cancer risk.

Original languageEnglish (US)
Title of host publicationCarcinogenesis
PublisherElsevier Inc.
Pages229-253
Number of pages25
Volume14
ISBN (Print)9780080468686
DOIs
StatePublished - Aug 12 2010

Keywords

  • 2-acetylaminoflourene
  • Breast
  • Calculi
  • Cell proliferation
  • Chemoprevention
  • Cytotoxicity
  • DNA reactivity
  • Forestomach
  • Hormones
  • Immunosuppression
  • Initiation
  • Kidney
  • Liver
  • Mitogenesis
  • Progression
  • Promotion
  • Regeneration
  • Stomach
  • Thyroid
  • Urinary bladder

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The Role of Cell Proliferation in the Etiology of Neoplasia'. Together they form a unique fingerprint.

  • Cite this