Abstract
Cancer is due to multiple genetic errors in a single stem cell fixed permanently during replication, produced either by directly damaging DNA or by increasing DNA replications. Synergies occur when both processes are produced. Cell proliferation can be increased by increasing cell births (direct mitogenicity or cytotoxicity and regeneration) or decreasing cell deaths (inhibit apoptosis or differentiation). Screening for these effects provides a rational basis for mode of action analysis and relevance of model findings to human cancer risk.
Original language | English (US) |
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Title of host publication | Carcinogenesis |
Publisher | Elsevier Inc. |
Pages | 229-253 |
Number of pages | 25 |
Volume | 14 |
ISBN (Print) | 9780080468686 |
DOIs | |
State | Published - Aug 12 2010 |
Keywords
- 2-acetylaminoflourene
- Breast
- Calculi
- Cell proliferation
- Chemoprevention
- Cytotoxicity
- DNA reactivity
- Forestomach
- Hormones
- Immunosuppression
- Initiation
- Kidney
- Liver
- Mitogenesis
- Progression
- Promotion
- Regeneration
- Stomach
- Thyroid
- Urinary bladder
ASJC Scopus subject areas
- General Medicine