The role of endotoxin in grain dust exposure and airway obstruction

Susanna Von Essen

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Grain dust exposure is a common cause of respiratory symptoms in grain workers, feed mill employees, and farmers. Many of these workers develop wheezing and acute and chronic bronchitis symptoms, which can be associated with obstructive changes on pulmonary function testing. It has recently been demonstrated that grain dust exposure causes neutrophilic airways inflammation and systemic symptoms related to release of interleukin-1, tumor necrosis factor, interleukin-6, and other mediators of inflammation. Although grain dust is a heterogenous substance, endotoxin has received the greatest amount of attention as a possible cause of the airway inflammation that occurs after grain dust exposure. Although endotoxin undoubtedly causes a portion of the changes seen after grain dust exposure, it is becoming clear that other substances play a role as well.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalCurrent Opinion in Pulmonary Medicine
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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