The role of hematopoietic stem cell transplant in follicular lymphoma

Edward A. Faber, Julie M. Vose

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Substantial progress has been made in the clinical management of patients with follicular lymphoma over the past 2 decades. However, the role of autologous and allogeneic stem cell transplantation in these patients remains controversial. Myeloablative chemotherapy or radioimmunotherapy supported by autologous hematopoietic cell transplantation has been shown to lead to a longer progression-free survival and, in some studies, improved survival over standard therapy. However, in the era of rituximab-based therapies used as part of induction or salvage, these historical trials may not be representative. Allogeneic stem cell transplantation offers the advantages of a tumor-free graft and some immunologic graft-versus-lymphoma effects. However, fully myeloablative transplants have high morbidity and mortality rates. Dose-reduced conditioning regimens followed by allogeneic hematopoietic cell transplantation have substantially reduced treatment-related mortality and perhaps will produce better outcomes long-term. This article outlines some historical information regarding stem cell transplantation for follicular lymphoma and discusses recent modifications that may improve outcomes, such as adding radio-immunotherapy to autologous stem cell transplantation or using alternative dose-reduced regimens that could benefit patients with reduced toxicities.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume8
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Autologous hematopoietic cell transplantation
  • Follicular lymphoma
  • Monoclonal antibodies
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Oncology

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