The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Janos Zempleni; Yong Li; Jing Xue; Elizabeth L. Cordonier

doi:10.4161/epi.6.7.15544

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Janos Zempleni, Yong Li, Jing Xue, Elizabeth L. Cordonier

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Holocarboxylase synthetase (HLCS) -catalyzes the covalent binding of biotin to histones. Biotinylated histones are gene repression marks and are particularly enriched in long terminal repeats, telomeres and other repeat regions. The effects of HLCS in gene regulation are mediated by its physical interactions with chromatin proteins such as histone H3, DNMT1, MeCP2 and EHMT-1. It appears that histone biotinylation depends on prior methylation of cytosines. De-repression of long terminal repeats in biotin- or HLCS-deficient cell cultures and organisms is associated with genome instability.

Original language	English (US)
Pages (from-to)	892-894
Number of pages	3
Journal	Epigenetics
Volume	6
Issue number	7
DOIs	https://doi.org/10.4161/epi.6.7.15544
State	Published - Jul 2011

Keywords

Biotin
DNMT1
EHMT-1
Genome stability
Histone
Holocarboxylase synthetase
MeCP2
Methylation

ASJC Scopus subject areas

Molecular Biology
Cancer Research

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10.4161/epi.6.7.15544

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title = "The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events",

abstract = "Holocarboxylase synthetase (HLCS) -catalyzes the covalent binding of biotin to histones. Biotinylated histones are gene repression marks and are particularly enriched in long terminal repeats, telomeres and other repeat regions. The effects of HLCS in gene regulation are mediated by its physical interactions with chromatin proteins such as histone H3, DNMT1, MeCP2 and EHMT-1. It appears that histone biotinylation depends on prior methylation of cytosines. De-repression of long terminal repeats in biotin- or HLCS-deficient cell cultures and organisms is associated with genome instability.",

keywords = "Biotin, DNMT1, EHMT-1, Genome stability, Histone, Holocarboxylase synthetase, MeCP2, Methylation",

author = "Janos Zempleni and Yong Li and Jing Xue and Cordonier, {Elizabeth L.}",

note = "Funding Information: A contribution of the University of Nebraska Agricultural Research Division, supported in part by funds provided through the Hatch Act. Additional support was provided by NIH grants DK063945, DK077816, DK082476 and ES015206, and USDA CSREES grant 2006-35200-17138.",

year = "2011",

month = jul,

doi = "10.4161/epi.6.7.15544",

language = "English (US)",

volume = "6",

pages = "892--894",

journal = "Epigenetics",

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AU - Zempleni, Janos

AU - Li, Yong

AU - Xue, Jing

AU - Cordonier, Elizabeth L.

N1 - Funding Information: A contribution of the University of Nebraska Agricultural Research Division, supported in part by funds provided through the Hatch Act. Additional support was provided by NIH grants DK063945, DK077816, DK082476 and ES015206, and USDA CSREES grant 2006-35200-17138.

PY - 2011/7

Y1 - 2011/7

N2 - Holocarboxylase synthetase (HLCS) -catalyzes the covalent binding of biotin to histones. Biotinylated histones are gene repression marks and are particularly enriched in long terminal repeats, telomeres and other repeat regions. The effects of HLCS in gene regulation are mediated by its physical interactions with chromatin proteins such as histone H3, DNMT1, MeCP2 and EHMT-1. It appears that histone biotinylation depends on prior methylation of cytosines. De-repression of long terminal repeats in biotin- or HLCS-deficient cell cultures and organisms is associated with genome instability.

AB - Holocarboxylase synthetase (HLCS) -catalyzes the covalent binding of biotin to histones. Biotinylated histones are gene repression marks and are particularly enriched in long terminal repeats, telomeres and other repeat regions. The effects of HLCS in gene regulation are mediated by its physical interactions with chromatin proteins such as histone H3, DNMT1, MeCP2 and EHMT-1. It appears that histone biotinylation depends on prior methylation of cytosines. De-repression of long terminal repeats in biotin- or HLCS-deficient cell cultures and organisms is associated with genome instability.

KW - Biotin

KW - DNMT1

KW - EHMT-1

KW - Genome stability

KW - Histone

KW - Holocarboxylase synthetase

KW - MeCP2

KW - Methylation

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JF - Epigenetics

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The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Abstract

Keywords

ASJC Scopus subject areas

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