The role of infiltrating macrophages in islet destruction and regrowth in a transgenic model

Danling Gu, Lorraine O'Reilly, Leslie Molony, Anne Cooke, Nora Sarvetnick

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The expression of interferon-gamma (IFN-γ) in pancreatic β cells leads to a complex pathology that represents the processes of both islet destruction and islet regeneration. Inflammatory cells and the factors elicited from them participate in the development of pathology in this transgenic model. To dissect the role of infiltrating macrophages in these events, the monoclonal directed against the type 3 complement receptor (5C6) was utilized to inhibit the extravasation of macrophages. This was approached by treating transgenic mice with 5C6 for 3 or 4 months, starting from 5-7 days of age. The data presented in this report demonstrate that infiltrating macrophages are important in the observed induction of diabetes in our transgenic model. We also found that infiltrating macrophages did not play a major role in the observed proliferation and islet regeneration, but some interesting subtleties regarding the regulation of this proliferative process emerged.

Original languageEnglish (US)
Pages (from-to)483-492
Number of pages10
JournalJournal of Autoimmunity
Volume8
Issue number4
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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