The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

RISE Study Group

doi:10.1016/j.dadm.2019.09.004

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

RISE Study Group

Electrical & Computer Engineering

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6 Scopus citations

Abstract

Introduction: The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [¹¹C]-PBR28 positron-emission tomography imaging. Methods: This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty-five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results: On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini-Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion: This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron-emission tomography with detailed clinical characterization of delirium, cognition, and functional status.

Original language	English (US)
Pages (from-to)	752-762
Number of pages	11
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	11
DOIs	https://doi.org/10.1016/j.dadm.2019.09.004
State	Published - Dec 1 2019

Keywords

Biomarkers
Cerebrospinal fluid
Delirium
Inflammation
Methods
Plasma
Positron emission tomography
Surgery

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.dadm.2019.09.004

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@article{eb15df8cf407406092c254ab120f87a7,

title = "The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile",

abstract = "Introduction: The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]-PBR28 positron-emission tomography imaging. Methods: This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty-five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results: On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini-Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion: This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron-emission tomography with detailed clinical characterization of delirium, cognition, and functional status.",

keywords = "Biomarkers, Cerebrospinal fluid, Delirium, Inflammation, Methods, Plasma, Positron emission tomography, Surgery",

author = "{RISE Study Group} and Hshieh, {Tammy T.} and Vasunilashorn, {Sarinnapha M.} and D'Aquila, {Madeline L.} and Arnold, {Steven E.} and Dickerson, {Bradford C.} and Fong, {Tamara G.} and Jones, {Richard N.} and Marcantonio, {Edward R.} and Schmitt, {Eva M.} and Guoquan Xu and Yun Gou and Fan Chen and Kunze, {Lisa J.} and Vlassakov, {Kamen V.} and Abdeen, {Ayesha R.} and Lange, {Jeffrey K.} and Earp, {Brandon E.} and Alexandra Touroutoglou and Carlyle, {Becky C.} and Pia Kivisakk-Webb and Travison, {Thomas G.} and Dillon, {Simon T.} and Libermann, {Towia A.} and Inouye, {Sharon K.} and Steven Arnold and Tamara Fong and Michele Cavallari and Jacob Hooker and Savannah Kandigian and Long Ngo and Hasan Otu and Bianca Trombetta and Ayesha Abdeen and Douglas Ayres and Gregory Brick and Antonia Chen and Robert Davis and Jacob Drew and Richard Iorio and Fulton Kornack and Michael Weaver and Anthony Webber and Richard Wilk and David Shaff and Brett Armstrong and Angelee Banda and Sylvie Bertrand and Jacqueline Gallagher and Baileigh Hightower and Shannon Malloy",

note = "Funding Information: The authors gratefully acknowledge the contributions of the patients, family members, nurses, physicians, staff members, and members of the Executive Committee who participated in the Role of Inflammation after Surgery in Elders (RISE) study. This work is dedicated to the memory of Joshua Bryan Inouye Helfand and Wanda Carr. Funding: This work was supported by grants from the Alzheimer's Drug Discovery Foundation (SKI) and 2P01AG031720 (SKI) from the National Institute on Aging. Other support of investigator time was provided by grants no. K07AG041835 (SKI), R24AG054259 (SKI), R01AG051658 (ERM/TAL), K24AG035075 (ERM), K01AG057836 (SMV), and R03AG061582 (SMV) from the National Institute on Aging and grant no. AARF-18-560786 (SMV) from the Alzheimer's Association. Dr. Inouye holds the Milton and Shirley F. Levy Family Chair at Hebrew SeniorLife/Harvard Medical School. RISE study group. [Presented in alphabetical order; individuals listed may be part of multiple groups, but are listed only once under major activity, listed in parentheses]. Principal Investigator: Sharon K. Inouye, MD, MPH (Overall PI; HSL, BIDMC, HMS). Executive Committee: Steven Arnold, MD (MGH); Bradford Dickerson, MD (MGH Site PI, HMS); Tamara Fong, MD, PhD (HMS, HSL, BIDMC); Richard Jones, ScD (Brown University); Towia A. Libermann, PhD (HMS, BIDMC); Edward R. Marcantonio, MD, SM (BIDMC Site PI, HMS); Thomas Travison, PhD (HSL, HMS). Co-Investigators: Becky C. Carlyle, PhD (HMS, MGH); Michele Cavallari, MD (BWH); Simon T. Dillon, PhD (HMS, BIDMC); Jacob Hooker, PhD, (MGH, HMS); Tammy Hshieh, MD, MPH (BWH); Savannah Kandigian, BA (MGH); Pia Kivisakk-Webb, MD, PhD (MGH), Long Ngo, PhD (HMS, BIDMC), Hasan Otu, PhD (UNL); Eva M. Schmitt, PhD (Overall Project Director, HSL); Alexandra Touroutoglou, PhD (HMS, MGH); Bianca Trombetta (MGH); Sarinnapha Vasunilashorn, PhD (BIDMC). Surgical Leaders: Ayesha Abdeen, MD (HMS, BIDMC); Douglas Ayres, MD (HMS, BIDMC); Brandon Earp, MD (HMS, BWH); Jeffrey Lange, MD (HMS, BWH). Surgeons: Gregory Brick, MBCHB (HMS, BWH); Antonia Chen, MD (HMS, BWH); Robert Davis, MD (HMS, BIDMC); Jacob Drew, MD (HMS, BIDMC); Richard Iorio, MD (HMS, BWH); Fulton Kornack, MD (HMS, BWH); Michael Weaver, MD (HMS, BWH); Anthony Webber, MD (HMS, BWH); Richard Wilk, MD (HMS, BWH). Anesthesiology Leaders: Lisa Kunze, MD (BIDMC, HMS); David Shaff, MD (BWH, HMS); Kamen Vlassakov, MD (BWH, HMS). Epidemiology Core: Brett Armstrong, MPH (BIDMC); Angelee Banda, MA (BIDMC); Sylvie Bertrand, BS (HSL); Madeline D'Aquila (HSL); Jacqueline Gallagher, MS (BIDMC); Baileigh Hightower, BA (MGH); Shannon Malloy, MA (BIDMC); Jacqueline Nee, BA (HSL); Chloe Nobuhara (MGH); Abigail Overstreet, MA (BIDMC); Annie Racine, PhD (HSL); David Urick (MGH); Guoquan Xu, MD, PhD (HSL). Biomedical Imaging Core: Grae Arabasz (MGH); Michael Brickhouse (MGH); Regan Butterfield (MGH); Shirley Hsu (MGH); Sara Makaretz (MGH); Judit Sore (MGH). Data Management and Statistical Analysis Core: Fan Chen, MPH, MS (HSL); Yun Gou, MA (HSL); Douglas Tommet, MS (Brown University). Fiscal Management Committee: Sabrina Carretie (HSL); Ted Gruen (HSL); Katherine Tasker (Chair, HSL). Funding Information: The authors gratefully acknowledge the contributions of the patients, family members, nurses, physicians, staff members, and members of the Executive Committee who participated in the Role of Inflammation after Surgery in Elders (RISE) study. This work is dedicated to the memory of Joshua Bryan Inouye Helfand and Wanda Carr. Funding: This work was supported by grants from the Alzheimer's Drug Discovery Foundation (SKI) and 2P01AG031720 (SKI) from the National Institute on Aging . Other support of investigator time was provided by grants no. K07AG041835 (SKI), R24AG054259 (SKI), R01AG051658 (ERM/TAL), K24AG035075 (ERM), K01AG057836 (SMV), and R03AG061582 (SMV) from the National Institute on Aging and grant no. AARF-18-560786 (SMV) from the Alzheimer's Association . Dr. Inouye holds the Milton and Shirley F. Levy Family Chair at Hebrew SeniorLife/Harvard Medical School. RISE study group. [Presented in alphabetical order; individuals listed may be part of multiple groups, but are listed only once under major activity, listed in parentheses]. Principal Investigator: Sharon K. Inouye, MD, MPH (Overall PI; HSL, BIDMC, HMS). Executive Committee: Steven Arnold, MD (MGH); Bradford Dickerson, MD (MGH Site PI, HMS); Tamara Fong, MD, PhD (HMS, HSL, BIDMC); Richard Jones, ScD (Brown University); Towia A. Libermann, PhD (HMS, BIDMC); Edward R. Marcantonio, MD, SM (BIDMC Site PI, HMS); Thomas Travison, PhD (HSL, HMS). Co-Investigators: Becky C. Carlyle, PhD (HMS, MGH); Michele Cavallari, MD (BWH); Simon T. Dillon, PhD (HMS, BIDMC); Jacob Hooker, PhD, (MGH, HMS); Tammy Hshieh, MD, MPH (BWH); Savannah Kandigian, BA (MGH); Pia Kivisakk-Webb, MD, PhD (MGH), Long Ngo, PhD (HMS, BIDMC), Hasan Otu, PhD (UNL); Eva M. Schmitt, PhD (Overall Project Director, HSL); Alexandra Touroutoglou, PhD (HMS, MGH); Bianca Trombetta (MGH); Sarinnapha Vasunilashorn, PhD (BIDMC). Surgical Leaders: Ayesha Abdeen, MD (HMS, BIDMC); Douglas Ayres, MD (HMS, BIDMC); Brandon Earp, MD (HMS, BWH); Jeffrey Lange, MD (HMS, BWH). Surgeons: Gregory Brick, MBCHB (HMS, BWH); Antonia Chen, MD (HMS, BWH); Robert Davis, MD (HMS, BIDMC); Jacob Drew, MD (HMS, BIDMC); Richard Iorio, MD (HMS, BWH); Fulton Kornack, MD (HMS, BWH); Michael Weaver, MD (HMS, BWH); Anthony Webber, MD (HMS, BWH); Richard Wilk, MD (HMS, BWH). Anesthesiology Leaders: Lisa Kunze, MD (BIDMC, HMS); David Shaff, MD (BWH, HMS); Kamen Vlassakov, MD (BWH, HMS). Epidemiology Core: Brett Armstrong, MPH (BIDMC); Angelee Banda, MA (BIDMC); Sylvie Bertrand, BS (HSL); Madeline D'Aquila (HSL); Jacqueline Gallagher, MS (BIDMC); Baileigh Hightower, BA (MGH); Shannon Malloy, MA (BIDMC); Jacqueline Nee, BA (HSL); Chloe Nobuhara (MGH); Abigail Overstreet, MA (BIDMC); Annie Racine, PhD (HSL); David Urick (MGH); Guoquan Xu, MD, PhD (HSL). Biomedical Imaging Core: Grae Arabasz (MGH); Michael Brickhouse (MGH); Regan Butterfield (MGH); Shirley Hsu (MGH); Sara Makaretz (MGH); Judit Sore (MGH). Data Management and Statistical Analysis Core: Fan Chen, MPH, MS (HSL); Yun Gou, MA (HSL); Douglas Tommet, MS (Brown University). Fiscal Management Committee: Sabrina Carretie (HSL); Ted Gruen (HSL); Katherine Tasker (Chair, HSL). Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.dadm.2019.09.004",

language = "English (US)",

volume = "11",

pages = "752--762",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - The Role of Inflammation after Surgery for Elders (RISE) study

T2 - Study design, procedures, and cohort profile

AU - RISE Study Group

AU - Hshieh, Tammy T.

AU - Vasunilashorn, Sarinnapha M.

AU - D'Aquila, Madeline L.

AU - Arnold, Steven E.

AU - Dickerson, Bradford C.

AU - Fong, Tamara G.

AU - Jones, Richard N.

AU - Marcantonio, Edward R.

AU - Schmitt, Eva M.

AU - Xu, Guoquan

AU - Gou, Yun

AU - Chen, Fan

AU - Kunze, Lisa J.

AU - Vlassakov, Kamen V.

AU - Abdeen, Ayesha R.

AU - Lange, Jeffrey K.

AU - Earp, Brandon E.

AU - Touroutoglou, Alexandra

AU - Carlyle, Becky C.

AU - Kivisakk-Webb, Pia

AU - Travison, Thomas G.

AU - Dillon, Simon T.

AU - Libermann, Towia A.

AU - Inouye, Sharon K.

AU - Arnold, Steven

AU - Fong, Tamara

AU - Cavallari, Michele

AU - Hooker, Jacob

AU - Kandigian, Savannah

AU - Ngo, Long

AU - Otu, Hasan

AU - Trombetta, Bianca

AU - Abdeen, Ayesha

AU - Ayres, Douglas

AU - Brick, Gregory

AU - Chen, Antonia

AU - Davis, Robert

AU - Drew, Jacob

AU - Iorio, Richard

AU - Kornack, Fulton

AU - Weaver, Michael

AU - Webber, Anthony

AU - Wilk, Richard

AU - Shaff, David

AU - Armstrong, Brett

AU - Banda, Angelee

AU - Bertrand, Sylvie

AU - Gallagher, Jacqueline

AU - Hightower, Baileigh

AU - Malloy, Shannon

N1 - Funding Information: The authors gratefully acknowledge the contributions of the patients, family members, nurses, physicians, staff members, and members of the Executive Committee who participated in the Role of Inflammation after Surgery in Elders (RISE) study. This work is dedicated to the memory of Joshua Bryan Inouye Helfand and Wanda Carr. Funding: This work was supported by grants from the Alzheimer's Drug Discovery Foundation (SKI) and 2P01AG031720 (SKI) from the National Institute on Aging. Other support of investigator time was provided by grants no. K07AG041835 (SKI), R24AG054259 (SKI), R01AG051658 (ERM/TAL), K24AG035075 (ERM), K01AG057836 (SMV), and R03AG061582 (SMV) from the National Institute on Aging and grant no. AARF-18-560786 (SMV) from the Alzheimer's Association. Dr. Inouye holds the Milton and Shirley F. Levy Family Chair at Hebrew SeniorLife/Harvard Medical School. RISE study group. [Presented in alphabetical order; individuals listed may be part of multiple groups, but are listed only once under major activity, listed in parentheses]. Principal Investigator: Sharon K. Inouye, MD, MPH (Overall PI; HSL, BIDMC, HMS). Executive Committee: Steven Arnold, MD (MGH); Bradford Dickerson, MD (MGH Site PI, HMS); Tamara Fong, MD, PhD (HMS, HSL, BIDMC); Richard Jones, ScD (Brown University); Towia A. Libermann, PhD (HMS, BIDMC); Edward R. Marcantonio, MD, SM (BIDMC Site PI, HMS); Thomas Travison, PhD (HSL, HMS). Co-Investigators: Becky C. Carlyle, PhD (HMS, MGH); Michele Cavallari, MD (BWH); Simon T. Dillon, PhD (HMS, BIDMC); Jacob Hooker, PhD, (MGH, HMS); Tammy Hshieh, MD, MPH (BWH); Savannah Kandigian, BA (MGH); Pia Kivisakk-Webb, MD, PhD (MGH), Long Ngo, PhD (HMS, BIDMC), Hasan Otu, PhD (UNL); Eva M. Schmitt, PhD (Overall Project Director, HSL); Alexandra Touroutoglou, PhD (HMS, MGH); Bianca Trombetta (MGH); Sarinnapha Vasunilashorn, PhD (BIDMC). Surgical Leaders: Ayesha Abdeen, MD (HMS, BIDMC); Douglas Ayres, MD (HMS, BIDMC); Brandon Earp, MD (HMS, BWH); Jeffrey Lange, MD (HMS, BWH). Surgeons: Gregory Brick, MBCHB (HMS, BWH); Antonia Chen, MD (HMS, BWH); Robert Davis, MD (HMS, BIDMC); Jacob Drew, MD (HMS, BIDMC); Richard Iorio, MD (HMS, BWH); Fulton Kornack, MD (HMS, BWH); Michael Weaver, MD (HMS, BWH); Anthony Webber, MD (HMS, BWH); Richard Wilk, MD (HMS, BWH). Anesthesiology Leaders: Lisa Kunze, MD (BIDMC, HMS); David Shaff, MD (BWH, HMS); Kamen Vlassakov, MD (BWH, HMS). Epidemiology Core: Brett Armstrong, MPH (BIDMC); Angelee Banda, MA (BIDMC); Sylvie Bertrand, BS (HSL); Madeline D'Aquila (HSL); Jacqueline Gallagher, MS (BIDMC); Baileigh Hightower, BA (MGH); Shannon Malloy, MA (BIDMC); Jacqueline Nee, BA (HSL); Chloe Nobuhara (MGH); Abigail Overstreet, MA (BIDMC); Annie Racine, PhD (HSL); David Urick (MGH); Guoquan Xu, MD, PhD (HSL). Biomedical Imaging Core: Grae Arabasz (MGH); Michael Brickhouse (MGH); Regan Butterfield (MGH); Shirley Hsu (MGH); Sara Makaretz (MGH); Judit Sore (MGH). Data Management and Statistical Analysis Core: Fan Chen, MPH, MS (HSL); Yun Gou, MA (HSL); Douglas Tommet, MS (Brown University). Fiscal Management Committee: Sabrina Carretie (HSL); Ted Gruen (HSL); Katherine Tasker (Chair, HSL). Funding Information: The authors gratefully acknowledge the contributions of the patients, family members, nurses, physicians, staff members, and members of the Executive Committee who participated in the Role of Inflammation after Surgery in Elders (RISE) study. This work is dedicated to the memory of Joshua Bryan Inouye Helfand and Wanda Carr. Funding: This work was supported by grants from the Alzheimer's Drug Discovery Foundation (SKI) and 2P01AG031720 (SKI) from the National Institute on Aging . Other support of investigator time was provided by grants no. K07AG041835 (SKI), R24AG054259 (SKI), R01AG051658 (ERM/TAL), K24AG035075 (ERM), K01AG057836 (SMV), and R03AG061582 (SMV) from the National Institute on Aging and grant no. AARF-18-560786 (SMV) from the Alzheimer's Association . Dr. Inouye holds the Milton and Shirley F. Levy Family Chair at Hebrew SeniorLife/Harvard Medical School. RISE study group. [Presented in alphabetical order; individuals listed may be part of multiple groups, but are listed only once under major activity, listed in parentheses]. Principal Investigator: Sharon K. Inouye, MD, MPH (Overall PI; HSL, BIDMC, HMS). Executive Committee: Steven Arnold, MD (MGH); Bradford Dickerson, MD (MGH Site PI, HMS); Tamara Fong, MD, PhD (HMS, HSL, BIDMC); Richard Jones, ScD (Brown University); Towia A. Libermann, PhD (HMS, BIDMC); Edward R. Marcantonio, MD, SM (BIDMC Site PI, HMS); Thomas Travison, PhD (HSL, HMS). Co-Investigators: Becky C. Carlyle, PhD (HMS, MGH); Michele Cavallari, MD (BWH); Simon T. Dillon, PhD (HMS, BIDMC); Jacob Hooker, PhD, (MGH, HMS); Tammy Hshieh, MD, MPH (BWH); Savannah Kandigian, BA (MGH); Pia Kivisakk-Webb, MD, PhD (MGH), Long Ngo, PhD (HMS, BIDMC), Hasan Otu, PhD (UNL); Eva M. Schmitt, PhD (Overall Project Director, HSL); Alexandra Touroutoglou, PhD (HMS, MGH); Bianca Trombetta (MGH); Sarinnapha Vasunilashorn, PhD (BIDMC). Surgical Leaders: Ayesha Abdeen, MD (HMS, BIDMC); Douglas Ayres, MD (HMS, BIDMC); Brandon Earp, MD (HMS, BWH); Jeffrey Lange, MD (HMS, BWH). Surgeons: Gregory Brick, MBCHB (HMS, BWH); Antonia Chen, MD (HMS, BWH); Robert Davis, MD (HMS, BIDMC); Jacob Drew, MD (HMS, BIDMC); Richard Iorio, MD (HMS, BWH); Fulton Kornack, MD (HMS, BWH); Michael Weaver, MD (HMS, BWH); Anthony Webber, MD (HMS, BWH); Richard Wilk, MD (HMS, BWH). Anesthesiology Leaders: Lisa Kunze, MD (BIDMC, HMS); David Shaff, MD (BWH, HMS); Kamen Vlassakov, MD (BWH, HMS). Epidemiology Core: Brett Armstrong, MPH (BIDMC); Angelee Banda, MA (BIDMC); Sylvie Bertrand, BS (HSL); Madeline D'Aquila (HSL); Jacqueline Gallagher, MS (BIDMC); Baileigh Hightower, BA (MGH); Shannon Malloy, MA (BIDMC); Jacqueline Nee, BA (HSL); Chloe Nobuhara (MGH); Abigail Overstreet, MA (BIDMC); Annie Racine, PhD (HSL); David Urick (MGH); Guoquan Xu, MD, PhD (HSL). Biomedical Imaging Core: Grae Arabasz (MGH); Michael Brickhouse (MGH); Regan Butterfield (MGH); Shirley Hsu (MGH); Sara Makaretz (MGH); Judit Sore (MGH). Data Management and Statistical Analysis Core: Fan Chen, MPH, MS (HSL); Yun Gou, MA (HSL); Douglas Tommet, MS (Brown University). Fiscal Management Committee: Sabrina Carretie (HSL); Ted Gruen (HSL); Katherine Tasker (Chair, HSL). Publisher Copyright: © 2019 The Authors

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]-PBR28 positron-emission tomography imaging. Methods: This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty-five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results: On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini-Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion: This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron-emission tomography with detailed clinical characterization of delirium, cognition, and functional status.

AB - Introduction: The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]-PBR28 positron-emission tomography imaging. Methods: This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty-five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results: On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini-Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion: This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron-emission tomography with detailed clinical characterization of delirium, cognition, and functional status.

KW - Biomarkers

KW - Cerebrospinal fluid

KW - Delirium

KW - Inflammation

KW - Methods

KW - Plasma

KW - Positron emission tomography

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=85074442037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074442037&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2019.09.004

DO - 10.1016/j.dadm.2019.09.004

M3 - Article

C2 - 31737775

AN - SCOPUS:85074442037

SN - 2352-8729

VL - 11

SP - 752

EP - 762

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

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Keywords

ASJC Scopus subject areas

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