The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

Melina Mitsiogianni, Georgios Koutsidis, Nikos Mavroudis, Dimitrios T. Trafalis, Sotiris Botaitis, Rodrigo Franco, Vasilis Zoumpourlis, Tom Amery, Alex Galanis, Aglaia Pappa, Mihalis I. Panayiotidis

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Many studies have shown evidence in support of the beneficial effects of hytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

Original languageEnglish (US)
Article number106
JournalAntioxidants
Volume8
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • Cell cycle
  • Chemo-therapy
  • Cruciferous vegetables
  • Glucosinolates
  • Growth arrest
  • Isothiocyanates
  • Malignant melanoma
  • Skin cancer

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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    Mitsiogianni, M., Koutsidis, G., Mavroudis, N., Trafalis, D. T., Botaitis, S., Franco, R., Zoumpourlis, V., Amery, T., Galanis, A., Pappa, A., & Panayiotidis, M. I. (2019). The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents. Antioxidants, 8(4), [106]. https://doi.org/10.3390/antiox8040106