TY - JOUR
T1 - The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents
AU - Mitsiogianni, Melina
AU - Koutsidis, Georgios
AU - Mavroudis, Nikos
AU - Trafalis, Dimitrios T.
AU - Botaitis, Sotiris
AU - Franco, Rodrigo
AU - Zoumpourlis, Vasilis
AU - Amery, Tom
AU - Galanis, Alex
AU - Pappa, Aglaia
AU - Panayiotidis, Mihalis I.
N1 - Funding Information:
Acknowledgments: The authors acknowledge support from Northumbria University at Newcastle, UK and specifically the Multidisciplinary Research Theme (MDRT) in Bio-economy (MP & MM).
Publisher Copyright:
© 2019 by the authors.
PY - 2019/4
Y1 - 2019/4
N2 - Many studies have shown evidence in support of the beneficial effects of hytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.
AB - Many studies have shown evidence in support of the beneficial effects of hytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.
KW - Cell cycle
KW - Chemo-therapy
KW - Cruciferous vegetables
KW - Glucosinolates
KW - Growth arrest
KW - Isothiocyanates
KW - Malignant melanoma
KW - Skin cancer
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U2 - 10.3390/antiox8040106
DO - 10.3390/antiox8040106
M3 - Review article
C2 - 31003534
AN - SCOPUS:85070673364
VL - 8
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 4
M1 - 106
ER -