The role of macrophage migration inhibitory factor on glucose metabolism and diabetes

C. Toso, J. A. Emamaullee, S. Merani, A. M.J. Shapiro

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in many inflammatory reactions and disorders, and it has become evident that it also affects glucose homeostasis. The protein is produced by pancreatic beta cells and can promote the release of insulin. It also modulates glucose uptake, glycolysis and insulin resistance in insulin target cells such as the adipocyte, myocyte and cardiomyocyte. Possessing both immunological and endocrinological properties, MIF has been associated with the development of type 1 and type 2 diabetes, and it may be important in the setting of islet transplantation. The present review summarises our current knowledge, based on clinical and research data, on the impact of MIF on both physiological and pathological aspects of glucose metabolism.

Original languageEnglish (US)
Pages (from-to)1937-1946
Number of pages10
JournalDiabetologia
Volume51
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Cytokine
  • Diabetes
  • Inflammation
  • Islet transplantation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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