The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses

Ghada A. Soliman

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR emerged as a central node in cellular metabolism, cell growth, and differentiation, as well as cancer metabolism. mTOR senses the nutrients, energy, insulin, growth factors, and environmental cues and transmits signals to downstream targets to effectuate the cellular and metabolic response. Recently, mTOR was also implicated in the regulation of both the innate and adaptive immune responses. This paper will summarize the current knowledge of mTOR, as related to the immune microenvironment and immune responses.

Original languageEnglish (US)
Pages (from-to)2231-2257
Number of pages27
JournalNutrients
Volume5
Issue number6
DOIs
StatePublished - Jun 19 2013

Keywords

  • Adaptive immunity
  • B cells
  • Immunosuppression
  • Innate immunity
  • Rapamycin
  • Regulatory T cells
  • T helper
  • mTOR
  • mTORC1
  • mTORC2

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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