The role of methotrexate in osteosarcoma

Jean L. Grem; Susan A. King; Robert E. Wittes; Brian Leyland-jones

doi:10.1093/jnci/80.9.626

The role of methotrexate in osteosarcoma

Jean L. Grem, Susan A. King, Robert E. Wittes, Brian Leyland-jones

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic dissues concerning MTX therapy in osteosarcoma are discussed. [J Natl Cancer Inst 1988;80:626-656].

Original language	English (US)
Pages (from-to)	626-655
Number of pages	30
Journal	Journal of the National Cancer Institute
Volume	80
Issue number	9
DOIs	https://doi.org/10.1093/jnci/80.9.626
State	Published - Jul 6 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "The role of methotrexate in osteosarcoma",

abstract = "High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic dissues concerning MTX therapy in osteosarcoma are discussed. [J Natl Cancer Inst 1988;80:626-656].",

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AU - King, Susan A.

AU - Wittes, Robert E.

AU - Leyland-jones, Brian

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N2 - High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic dissues concerning MTX therapy in osteosarcoma are discussed. [J Natl Cancer Inst 1988;80:626-656].

AB - High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic dissues concerning MTX therapy in osteosarcoma are discussed. [J Natl Cancer Inst 1988;80:626-656].

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