The role of microRNAs in acute myeloid leukemia

R. Katherine Hyde; P. Paul Liu

doi:10.3410/B2-81

The role of microRNAs in acute myeloid leukemia

R. Katherine Hyde, P. Paul Liu

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

MicroRNAs (miRs) are short (18-22 nucleotides) non-coding RNAs that are important in regulating gene expression. MiR expression is deregulated in many types of cancers, including leukemias. In acute myeloid leukemia (AML), the expression of specific miRs has been linked with both prognostically and cytogenetically defined subgroups. Recent studies have shown that deregulation of miR expression is not simply a consequence of AML but a potential contributer to leukemogenesis. This commentary will focus on select findings that describe the different mechanistic roles for miRs in the development of leukemia.

Original language	English (US)
Article number	81
Journal	F1000 Biology Reports
Volume	2
Issue number	1
DOIs	https://doi.org/10.3410/B2-81
State	Published - Nov 24 2010
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
Pharmacology, Toxicology and Pharmaceutics(all)

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AB - MicroRNAs (miRs) are short (18-22 nucleotides) non-coding RNAs that are important in regulating gene expression. MiR expression is deregulated in many types of cancers, including leukemias. In acute myeloid leukemia (AML), the expression of specific miRs has been linked with both prognostically and cytogenetically defined subgroups. Recent studies have shown that deregulation of miR expression is not simply a consequence of AML but a potential contributer to leukemogenesis. This commentary will focus on select findings that describe the different mechanistic roles for miRs in the development of leukemia.

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The role of microRNAs in acute myeloid leukemia

Abstract

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