Abstract
Objective: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design: Prospective study; institutional review board-approved clinical trial. Setting: Tertiary care pediatric medical center. Patients: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome: The efficacy and safety of mitomycin in the prevention of scar formation. Intervention: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 401-406 |
| Number of pages | 6 |
| Journal | Archives of Otolaryngology - Head and Neck Surgery |
| Volume | 128 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology