The role of nuclear factor-κ B in pulmonary diseases

John W. Christman, Ruxana T. Sadikot, Timothy S. Blackwell

Research output: Contribution to journalArticlepeer-review

293 Scopus citations

Abstract

Nuclear factor-κ B (NF-κB) is a family of DNA-binding protein factors that are required for I transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. NF-κB activation seems to be a key early event in a variety of cell and I animal model systems developed to elucidate the pathobiology of lung diseases. The purpose of this short review is to describe what is known about the molecular biology of NF-κB and to review information that implicates NF-κB in the pathogenesis of lung disease, including ABDS, systemic inflammatory response syndrome, asthma, respiratory viral infections, occupational and environmental lung disease, and cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)1482-1487
Number of pages6
JournalChest
Volume117
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • ARDS
  • Air pollution
  • Asbestosis
  • Asthma
  • Ozone
  • Respiratory syncytial virus
  • Rhinovirus
  • Sepsis
  • Silicosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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