TY - JOUR
T1 - The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development
AU - Ziech, Dominique
AU - Franco, Rodrigo
AU - Georgakilas, Alexandros G.
AU - Georgakila, Stavroula
AU - Malamou-Mitsi, Vasiliki
AU - Schoneveld, Onard
AU - Pappa, Aglaia
AU - Panayiotidis, Mihalis I.
N1 - Funding Information:
This work was supported, in part, by the National Institutes of Health (Grant# P20RR17675 ), Centers of Biomedical Research Excellence (COBRE) and Layman Award form the University of Nebraska-Lincoln (Dr. Franco); the Biology Department and a Research/Creative Activity Grant Award from the University of East Carolina as well as an UICC-ICRETT 2008 Fellowship (Dr. Georgakilas); a Marie Curie International Reintegration Grant within the 6th European Community Framework Program (MIRG-CT-2006-036585) (Dr. Pappa); and the School of Community Health Sciences and a Junior Faculty Research Award from the University of Nevada-Ren o (Dr. Panayiotidis).
PY - 2010/11
Y1 - 2010/11
N2 - Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.
AB - Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.
KW - Biomarkers
KW - Environmental carcinogenesis
KW - Oxidative DNA damage
KW - Oxidative stress
KW - ROS
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U2 - 10.1016/j.cbi.2010.07.010
DO - 10.1016/j.cbi.2010.07.010
M3 - Review article
C2 - 20637748
AN - SCOPUS:77956651323
SN - 0009-2797
VL - 188
SP - 334
EP - 339
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 2
ER -