The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development

Dominique Ziech, Rodrigo Franco, Alexandros G. Georgakilas, Stavroula Georgakila, Vasiliki Malamou-Mitsi, Onard Schoneveld, Aglaia Pappa, Mihalis I. Panayiotidis

Research output: Contribution to journalReview article

157 Scopus citations

Abstract

Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.

Original languageEnglish (US)
Pages (from-to)334-339
Number of pages6
JournalChemico-Biological Interactions
Volume188
Issue number2
DOIs
StatePublished - Nov 2010

Keywords

  • Biomarkers
  • Environmental carcinogenesis
  • Oxidative DNA damage
  • Oxidative stress
  • ROS

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development'. Together they form a unique fingerprint.

  • Cite this

    Ziech, D., Franco, R., Georgakilas, A. G., Georgakila, S., Malamou-Mitsi, V., Schoneveld, O., Pappa, A., & Panayiotidis, M. I. (2010). The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chemico-Biological Interactions, 188(2), 334-339. https://doi.org/10.1016/j.cbi.2010.07.010