Abstract
Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.
Original language | English (US) |
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Pages (from-to) | 98-104 |
Number of pages | 7 |
Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
Volume | 126 |
DOIs | |
State | Published - Nov 2017 |
Keywords
- Docosahexaenoic acid
- Fetal health
- Omega-3 fatty acid
- Pregnancy
- Pro-resolving lipid mediator
- Resolvins
ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology