The role of specialized pro-resolving mediators in maternal-fetal health

E. Elliott; C. K. Hanson; A. L. Anderson-Berry; T. M. Nordgren

doi:10.1016/j.plefa.2017.09.017

The role of specialized pro-resolving mediators in maternal-fetal health

E. Elliott, C. K. Hanson, A. L. Anderson-Berry, T. M. Nordgren

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

Original language	English (US)
Pages (from-to)	98-104
Number of pages	7
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	126
DOIs	https://doi.org/10.1016/j.plefa.2017.09.017
State	Published - Nov 2017

Keywords

Docosahexaenoic acid
Fetal health
Omega-3 fatty acid
Pregnancy
Pro-resolving lipid mediator
Resolvins

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

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10.1016/j.plefa.2017.09.017

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title = "The role of specialized pro-resolving mediators in maternal-fetal health",

abstract = "Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.",

keywords = "Docosahexaenoic acid, Fetal health, Omega-3 fatty acid, Pregnancy, Pro-resolving lipid mediator, Resolvins",

author = "E. Elliott and Hanson, {C. K.} and Anderson-Berry, {A. L.} and Nordgren, {T. M.}",

note = "Funding Information: Authors gratefully acknowledge funding support by NIEHS K99ES025819 (TMN). Funding Information: This work was supported by the National Institutes of Health [NIEHS K99ES025819 to TMN] Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = nov,

doi = "10.1016/j.plefa.2017.09.017",

language = "English (US)",

volume = "126",

pages = "98--104",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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AU - Elliott, E.

AU - Hanson, C. K.

AU - Anderson-Berry, A. L.

AU - Nordgren, T. M.

N1 - Funding Information: Authors gratefully acknowledge funding support by NIEHS K99ES025819 (TMN). Funding Information: This work was supported by the National Institutes of Health [NIEHS K99ES025819 to TMN] Publisher Copyright: © 2017 Elsevier Ltd

PY - 2017/11

Y1 - 2017/11

N2 - Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

AB - Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

KW - Docosahexaenoic acid

KW - Fetal health

KW - Omega-3 fatty acid

KW - Pregnancy

KW - Pro-resolving lipid mediator

KW - Resolvins

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DO - 10.1016/j.plefa.2017.09.017

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ER -

The role of specialized pro-resolving mediators in maternal-fetal health

Abstract

Keywords

ASJC Scopus subject areas

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