The role of systemic inflammation in COPD

Kristina L. Bailey; Jadvinder Goraya; Stephen L. Rennard

doi:10.1007/978-1-60761-673-3_2

The role of systemic inflammation in COPD

Kristina L. Bailey, Jadvinder Goraya, Stephen L. Rennard

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Many of the extrapulmonary effects of COPD are thought to be mediated by systemic inflammation. Local inflammation has always been appreciated as part of the COPD disease process; however, it is becoming clear that the inflammatory response is also systemic. There are multiple theories about the mechanisms driving the systemic inflammation associated with COPD. However, there is no consensus on which theory is correct. The systemic inflammation likely contributes to systemic manifestations of COPD, including cardiovascular disease, lung cancer, weight loss, osteoporosis and diabetes.

Original language	English (US)
Title of host publication	Chronic Obstructive Pulmonary Disease
Subtitle of host publication	Co-Morbidities and Systemic Consequences
Publisher	Humana Press Inc.
Pages	15-30
Number of pages	16
ISBN (Electronic)	9781607616733
ISBN (Print)	9781607616726
DOIs	https://doi.org/10.1007/978-1-60761-673-3_2
State	Published - Jan 1 2012

Keywords

C-reactive proteins
COPD
Cytokines
Disease severity
Extrapulmonary effects
Interleukin
Local inflammation
Lung parenchyma
Systemic
Tumor necrosis alpha

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-60761-673-3_2

Cite this

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abstract = "Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Many of the extrapulmonary effects of COPD are thought to be mediated by systemic inflammation. Local inflammation has always been appreciated as part of the COPD disease process; however, it is becoming clear that the inflammatory response is also systemic. There are multiple theories about the mechanisms driving the systemic inflammation associated with COPD. However, there is no consensus on which theory is correct. The systemic inflammation likely contributes to systemic manifestations of COPD, including cardiovascular disease, lung cancer, weight loss, osteoporosis and diabetes.",

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AB - Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Many of the extrapulmonary effects of COPD are thought to be mediated by systemic inflammation. Local inflammation has always been appreciated as part of the COPD disease process; however, it is becoming clear that the inflammatory response is also systemic. There are multiple theories about the mechanisms driving the systemic inflammation associated with COPD. However, there is no consensus on which theory is correct. The systemic inflammation likely contributes to systemic manifestations of COPD, including cardiovascular disease, lung cancer, weight loss, osteoporosis and diabetes.

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KW - Local inflammation

KW - Lung parenchyma

KW - Systemic

KW - Tumor necrosis alpha

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The role of systemic inflammation in COPD

Abstract

Keywords

ASJC Scopus subject areas

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