The role of systemic inflammation in COPD

Kristina L. Bailey, Jadvinder Goraya, Stephen L. Rennard

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Many of the extrapulmonary effects of COPD are thought to be mediated by systemic inflammation. Local inflammation has always been appreciated as part of the COPD disease process; however, it is becoming clear that the inflammatory response is also systemic. There are multiple theories about the mechanisms driving the systemic inflammation associated with COPD. However, there is no consensus on which theory is correct. The systemic inflammation likely contributes to systemic manifestations of COPD, including cardiovascular disease, lung cancer, weight loss, osteoporosis and diabetes.

Original languageEnglish (US)
Title of host publicationChronic Obstructive Pulmonary Disease
Subtitle of host publicationCo-Morbidities and Systemic Consequences
PublisherHumana Press Inc.
Number of pages16
ISBN (Electronic)9781607616733
ISBN (Print)9781607616726
StatePublished - Jan 1 2012


  • C-reactive proteins
  • COPD
  • Cytokines
  • Disease severity
  • Extrapulmonary effects
  • Interleukin
  • Local inflammation
  • Lung parenchyma
  • Systemic
  • Tumor necrosis alpha

ASJC Scopus subject areas

  • General Medicine


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