TY - JOUR
T1 - The role of the amygdala and rostral anterior cingulate in encoding expected outcomes during learning
AU - Kosson, D. S.
AU - Budhani, S.
AU - Nakic, M.
AU - Chen, G.
AU - Saad, Z. S.
AU - Vythilingam, M.
AU - Pine, D. S.
AU - Blair, R. J.R.
N1 - Funding Information:
This work was supported by Grant MH57714 from the National Institute of Mental Health to D.S. Kosson and a Medical Research Council studentship grant to S. Budhani.
PY - 2006/2/15
Y1 - 2006/2/15
N2 - Successful passive avoidance learning is thought to require the use of learned stimulus-reinforcement associations to guide decision making [Baxter, M.G., Murray, E.A., 2002. The amygdala and reward. Nature Reviews. Neuroscience 3, 563-573]. The current experiment investigated the neural correlates of successful passive avoidance learning in 19 healthy adults. Behaviorally, subjects showed a distinct pattern of performance: early indiscriminate responding to stimuli (pre-criterion performance), followed by relatively rapid learning before a plateau of successful performance (post-criterion performance). Neural responses to post-criterion correct responses were compared with neural responses to both incorrect responses and pre-criterion correct responses. Post-criterion correct responding was associated with increased activation in regions including rostral anterior cingulate, insula, caudate, hippocampal regions, and the amygdala.
AB - Successful passive avoidance learning is thought to require the use of learned stimulus-reinforcement associations to guide decision making [Baxter, M.G., Murray, E.A., 2002. The amygdala and reward. Nature Reviews. Neuroscience 3, 563-573]. The current experiment investigated the neural correlates of successful passive avoidance learning in 19 healthy adults. Behaviorally, subjects showed a distinct pattern of performance: early indiscriminate responding to stimuli (pre-criterion performance), followed by relatively rapid learning before a plateau of successful performance (post-criterion performance). Neural responses to post-criterion correct responses were compared with neural responses to both incorrect responses and pre-criterion correct responses. Post-criterion correct responding was associated with increased activation in regions including rostral anterior cingulate, insula, caudate, hippocampal regions, and the amygdala.
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U2 - 10.1016/j.neuroimage.2005.07.060
DO - 10.1016/j.neuroimage.2005.07.060
M3 - Article
C2 - 16387514
AN - SCOPUS:31844440020
SN - 1053-8119
VL - 29
SP - 1161
EP - 1172
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -