The roles of thiol oxidoreductases in yeast replicative aging

Elise Hacioglu; Isil Esmer; Dmitri E. Fomenko; Vadim N. Gladyshev; Ahmet Koc

doi:10.1016/j.mad.2010.09.006

The roles of thiol oxidoreductases in yeast replicative aging

Elise Hacioglu, Isil Esmer, Dmitri E. Fomenko, Vadim N. Gladyshev, Ahmet Koc

Biochemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.

Original language	English (US)
Pages (from-to)	692-699
Number of pages	8
Journal	Mechanisms of Ageing and Development
Volume	131
Issue number	11-12
DOIs	https://doi.org/10.1016/j.mad.2010.09.006
State	Published - Nov 2010

Keywords

Aging
Antioxidant
Life span
Oxidation
Oxidoreductase
Yeast

ASJC Scopus subject areas

Aging
Developmental Biology

Access to Document

10.1016/j.mad.2010.09.006

Cite this

@article{ef7cf7367d9d4c27afa934c97ba9ee61,

title = "The roles of thiol oxidoreductases in yeast replicative aging",

abstract = "Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.",

keywords = "Aging, Antioxidant, Life span, Oxidation, Oxidoreductase, Yeast",

author = "Elise Hacioglu and Isil Esmer and Fomenko, {Dmitri E.} and Gladyshev, {Vadim N.} and Ahmet Koc",

note = "Funding Information: We thank the Biotechnology Center and Biological Mass Spectra facility of Izmir Institute of Technology for help with instrumentation. This work was supported by DPT-2003K120690 and T{\"U}BA-GEBİP grants (to AK) and by NIH AG021518 (to VNG).",

year = "2010",

month = nov,

doi = "10.1016/j.mad.2010.09.006",

language = "English (US)",

volume = "131",

pages = "692--699",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "11-12",

}

TY - JOUR

T1 - The roles of thiol oxidoreductases in yeast replicative aging

AU - Hacioglu, Elise

AU - Esmer, Isil

AU - Fomenko, Dmitri E.

AU - Gladyshev, Vadim N.

AU - Koc, Ahmet

N1 - Funding Information: We thank the Biotechnology Center and Biological Mass Spectra facility of Izmir Institute of Technology for help with instrumentation. This work was supported by DPT-2003K120690 and TÜBA-GEBİP grants (to AK) and by NIH AG021518 (to VNG).

PY - 2010/11

Y1 - 2010/11

N2 - Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.

AB - Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.

KW - Aging

KW - Antioxidant

KW - Life span

KW - Oxidation

KW - Oxidoreductase

KW - Yeast

UR - http://www.scopus.com/inward/record.url?scp=78649909154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649909154&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2010.09.006

DO - 10.1016/j.mad.2010.09.006

M3 - Article

C2 - 20934449

AN - SCOPUS:78649909154

SN - 0047-6374

VL - 131

SP - 692

EP - 699

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 11-12

ER -

The roles of thiol oxidoreductases in yeast replicative aging

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this