The roles of thiol oxidoreductases in yeast replicative aging

Elise Hacioglu, Isil Esmer, Dmitri E. Fomenko, Vadim N. Gladyshev, Ahmet Koc

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.

Original languageEnglish (US)
Pages (from-to)692-699
Number of pages8
JournalMechanisms of Ageing and Development
Volume131
Issue number11-12
DOIs
StatePublished - Nov 2010

Keywords

  • Aging
  • Antioxidant
  • Life span
  • Oxidation
  • Oxidoreductase
  • Yeast

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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