The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

Stephen I. Rennard, Charles Fogarty, Steven Kelsen, William Long, Joe Ramsdell, James Allison, Donald Mahler, Constantine Saadeh, Thomas Siler, Phillip Snell, Phillip Korenblat, William Smith, Mitchell Kaye, Michael Mandel, Charles Andrews, Rachakonda Prabhu, James F. Donohue, Rosemary Watt, Hung Lo Kim, Rozsa Schlenker-HercegElliot S. Barnathan, John Murray

Research output: Contribution to journalArticle

323 Scopus citations

Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-α is overexpressed and has been suggested to play a pathogenic role. Objectives: To determine if infliximab, an anti-TNF-α antibody, results in clinical benefit and has an acceptable safety profile in patients with moderate to severe COPD. Methods: In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study, subjects with moderate to severe COPD received infliximab (3 mg/kg [n = 78] or 5 mg/kg [n = 79]) or placebo (n = 77) at Weeks 0, 2, 6, 12, 18, and 24. Efficacy, health status, and safety were assessed through Week 44. Measurements and Main Results: Infliximab was generally well tolerated, but showed no treatment benefit as measured by the primary endpoint, Chronic Respiratory Questionnaire total score. Similarly, there was no change in secondary measures, including prebronchodilator FEV1, 6-min walk distance, SF-36 physical score, transition dyspnea index, or moderate-to-severe COPD exacerbations. Post hoc analysis revealed that subjects who were younger or cachectic showed improvement in the 6-min walk distance. Malignancies were diagnosed during the study in 9 of 157 infliximab-treated subjects versus 1 of 77 placebo-treated subjects. No opportunistic infections were observed, and there were no differences in the occurrence of antibiotic-requiring infections, although the incidence of pneumonia was higher in infliximab-treated subjects. No infection-related mortality was observed. Higher proportions of infliximab-treated subjects discontinued the study agent due to adverse events (20-27%) than did placebo-treated subjects (9%). Conclusions: Subjects with moderate to severe COPD did not benefit from treatment with infliximab. Although not statistically significant, more cases of cancer and pneumonia were observed in the infliximab-treated subjects. The impact of infliximab on malignancy risk in patients with COPD needs to be further elucidated.

Original languageEnglish (US)
Pages (from-to)926-934
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume175
Issue number9
DOIs
StatePublished - May 1 2007

Keywords

  • Chronic obstructive pulmonary disease
  • Infliximab
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Rennard, S. I., Fogarty, C., Kelsen, S., Long, W., Ramsdell, J., Allison, J., Mahler, D., Saadeh, C., Siler, T., Snell, P., Korenblat, P., Smith, W., Kaye, M., Mandel, M., Andrews, C., Prabhu, R., Donohue, J. F., Watt, R., Kim, H. L., ... Murray, J. (2007). The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 175(9), 926-934. https://doi.org/10.1164/rccm.200607-995OC