The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection

Insun Kook, Clinton Jones

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Serum and glucocorticoid-regulated protein kinases (SGK) are serine/threonine protein kinases that contain a catalytic domain resembling other protein kinases: AKT/protein kinase B, protein kinase A, and protein kinase C-Zeta for example. Unlike these constitutively expressed protein kinases, SGK1 RNA and protein levels are increased by growth factors and corticosteroids. Stress can directly stimulate SGK1 levels as well as stimulate bovine herpesvirus 1 (BoHV-1) and herpes simplex virus 1 (HSV-1) productive infection and reactivation from latency suggesting SGK1 can stimulate productive infection. For the first time, we provide evidence that a specific SGK inhibitor (GSK650394) significantly reduced BoHV-1 and HSV-1 replication in cultured cells. Proteins encoded by the three BoHV-1 immediate early genes (bICP0, bICP4, and bICP22) and two late proteins (VP16 and gE) were consistently reduced by GSK650394 during early stages of productive infection. In summary, these studies suggest SGK may stimulate viral replication following stressful stimuli.

Original languageEnglish (US)
Pages (from-to)106-112
Number of pages7
JournalVirus Research
Volume222
DOIs
StatePublished - Aug 15 2016

Keywords

  • Bovine herpesvirus 1 (BoHV-1)
  • Herpes simplex virus 1 (HSV-1)
  • Productive infection
  • Serum and glucocorticoid-regulated protein kinases

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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