The signaling and apoptotic effects of TNF-related apoptosis-inducing ligand in HIV-1 associated dementia

Y. Huang, N. Erdmann, J. Zhao, J. Zheng

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

HIV-1 Associated Dementia (HAD) develops during progressive HIV-1 infection and is characterized by cognitive impairments, behavioral disorders and potential progressive motor abnormality. Abnormal inflammation within the central nervous system (CNS), activation of macrophage/microglia and involvement of proinflammatory cytokines have been suggested as primary factors in the pathogenesis of HAD. Impairment of neuronal function and neuronal cell death are believed to be the end pathophysiological result of HAD. TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family of cytokines, was suggested to participate in apoptotic cell death during HAD. As a death ligand, TRAIL was originally thought to target only tumor cells. TRAIL is not typically present in CNS; however, emerging data show that TRAIL can be induced by immune stimuli on macrophage and microglia, major disease effector cells during HAD. Upregulated TRAIL may then cause neuronal apoptosis through direct interaction with TRAIL receptors on neurons or through macrophage death-mediated release of neurotoxins. In this review, we summarize the pivotal role of TRAIL in HAD and TRAIL-initiated intracellular death cascades that culminate in neuronal apoptosis as observed in HAD.

Original languageEnglish (US)
Pages (from-to)135-148
Number of pages14
JournalNeurotoxicity Research
Volume8
Issue number1-2
DOIs
StatePublished - 2005

Keywords

  • Apoptosis
  • HIV-1 associated dementia
  • Macrophage
  • Neurons
  • TRAIL

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Fingerprint Dive into the research topics of 'The signaling and apoptotic effects of TNF-related apoptosis-inducing ligand in HIV-1 associated dementia'. Together they form a unique fingerprint.

  • Cite this