TY - JOUR
T1 - The significance of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders
T2 - A review
AU - Mohan, Akansha
AU - Roberto, Aaron J.
AU - Mohan, Abhishek
AU - Lorenzo, Aileen
AU - Jones, Kathryn
AU - Carney, Martin J.
AU - Liogier-Weyback, Luis
AU - Hwang, Soonjo
AU - Lapidus, Kyle A.B.
N1 - Publisher Copyright:
© 2016.
PY - 2016/3
Y1 - 2016/3
N2 - The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.
AB - The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.
KW - Alzheimer’s disease
KW - Attention deficit hyperactivity disorder
KW - Default Mode Network
KW - Mood disorder
KW - Parkinson’s disease
KW - Resting State Functional Magnetic Resonance Imaging
KW - Temporal Lobe Epilepsy
UR - http://www.scopus.com/inward/record.url?scp=84962034289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962034289&partnerID=8YFLogxK
M3 - Review article
C2 - 27505016
AN - SCOPUS:84962034289
SN - 0044-0086
VL - 89
SP - 49
EP - 57
JO - Yale Journal of Biology and Medicine
JF - Yale Journal of Biology and Medicine
IS - 1
ER -