The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease

Allie H. Grossmann, Helong Zhao, Noah Jenkins, Weiquan Zhu, Jackson R. Richards, Jae Hyuk Yoo, Jacob M. Winter, Bianca Rich, Tara M. Mleynek, Dean Y. Li, Shannon J. Odelberg

Research output: Contribution to journalComment/debatepeer-review

13 Scopus citations

Abstract

The activation of the small GTPase ARF6 has been implicated in promoting several pathological processes related to vascular instability and tumor formation, growth, and metastasis. ARF6 also plays a vital role during embryonic development. Recent studies have suggested that ARF6 carries out these disparate functions primarily by controlling protein trafficking within the cell. ARF6 helps direct proteins to intracellular or extracellular locations where they function in normal cellular responses during development and in pathological processes later in life. This transport of proteins is accomplished through a variety of mechanisms, including endocytosis and recycling, microvesicle release, and as yet uncharacterized processes. This Commentary will explore the functions of ARF6, while focusing on the role of this small GTPase in development and postnatal physiology, regulating barrier function and diseases associated with its loss, and tumor formation, growth, and metastasis.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalSmall GTPases
Volume10
Issue number1
DOIs
StatePublished - Jan 2 2019
Externally publishedYes

Keywords

  • adenosine diphosphate ribosylation factor 6
  • ARF6, barrier function
  • cancer
  • development
  • metastasis
  • postnatal physiology
  • protein trafficking
  • tumor growth
  • vascular stability

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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