The somnolence syndrome in leukemic children following reduced daily dose fractions of cranial radiation

Philip Littman, Jeffrey Rosenstock, Gordon Gale, Robert E. Krisch, Anna Meadows, Harlan Sather, Peter Coccia, Beatriz Decamargo

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A group of children with acute lymphocytic leukemia was studied to investigate if a reduction in daily dose fraction of cranial radiation would reduce the incidence of somnolence syndrome. Thirty-one evaluable patients received 100 rad × 18 cranial radiation therapy. Sixty-six similar evaluable patients were given 180 rad × 10. Both groups received the same chemotherapy including intrathecal methotrexate. Clinically detectable somnolence appeared in 58% of ech group without significant differences in the overall frequency or severity of somnolence (p > 0.5. This study failed to substantiate a radiation dose fraction size dependence for somnolence syndrome in children with acute lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)1851-1853
Number of pages3
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume10
Issue number10
DOIs
StatePublished - Oct 1984
Externally publishedYes

Keywords

  • Acute lymphocytic leukemia
  • Central nervous system leukemia
  • Somnolence syndrome

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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