The spectrum of orbital Rosai-Dorfman disease

Yasaman Mohadjer, John B. Holds, Jack Rootman, Mathew W. Wilson, James W. Gigantelli, Philip L. Custer

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

PURPOSE: To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases. METHODS: Retrospective, interventional case series of seven patients and literature review. RESULTS: Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable. CONCLUSIONS: Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalOphthalmic Plastic and Reconstructive Surgery
Volume22
Issue number3
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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    Mohadjer, Y., Holds, J. B., Rootman, J., Wilson, M. W., Gigantelli, J. W., & Custer, P. L. (2006). The spectrum of orbital Rosai-Dorfman disease. Ophthalmic Plastic and Reconstructive Surgery, 22(3), 163-168. https://doi.org/10.1097/01.iop.0000217563.00975.a3