The spin trapping of superoxide with M4PO (3,3,5,5-Tetramethylpyrroline-N-oxide)

Garry R. Buettner, Bradley E. Britigan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The spin trap 3,3,5,5-tetramethylpyrroline-N-oxide (M4PO) reacts with superoxide to produce a short-lived spin adduct (M4PO/·OOH, AN = 14.0 G, AH = 6.5 G) that decays by a first-order process (t 1 2 ≈ 35 s at pH 7.4). This short lifetime may limit its usefulness in studies of superoxide.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalFree Radical Biology and Medicine
Issue number1
StatePublished - 1990
Externally publishedYes


  • 3,3,5-5-Tetramethylpyrroline-N-oxide (MPO)
  • Free radicals
  • Hydrated electron
  • Hydroxyl radical
  • Spin trapping
  • Superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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