The synthesis and compositional analysis of phosphopeptides

Sam D. Sanderson, Fulvio Perini

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Protein phosphorylation plays a critical role in the regulation of cell growth and differentiation, There is considerable interest, therefore, in the facile synthesis of peptides that possess selectively phosphorylated residues for use as molecular probes in mechanistic studies of the biological consequences of phosphorylation. This work will review the various synthetic protocols used in the generation of phosphopeptides and will discuss their characterization by amino acid compositional analysis.

Original languageEnglish (US)
Pages (from-to)139-149
Number of pages11
JournalMolecular Biotechnology
Volume4
Issue number2
DOIs
StatePublished - Oct 1995

Keywords

  • Phosphorylation
  • phosphoamino acids
  • phosphopeptides

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

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