The target tissue in autoimmunity - An influential niche

Natasha J. Hill, Monica Hultcrantz, Nora Sarvetnick, Malin Flodström-Tullberg

Research output: Contribution to journalShort surveypeer-review

24 Scopus citations


Central and peripheral tolerance mechanisms were for a long time the only regulatory circuits known in autoimmunity. It is now becoming clear that the target tissue itself may have the capacity to control its own destiny. Here we review mechanisms by which the target tissue regulates local inflammation, and the way this could influence progression to overt autoimmunity. Moreover, we discuss recent data showing that physiological properties of the target tissue can determine the organ specificity of autoimmune disease. These recent discoveries and ideas concerning the regulatory potential of the target tissue may, in the future, add a new dimension to our concept of regulatory circuits in autoimmunity.

Original languageEnglish (US)
Pages (from-to)589-597
Number of pages9
JournalEuropean Journal of Immunology
Issue number3
StatePublished - Mar 2007
Externally publishedYes


  • Autoimmune
  • Costimulation
  • Cytokines
  • Diabetes
  • Target cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'The target tissue in autoimmunity - An influential niche'. Together they form a unique fingerprint.

Cite this