The three-dimensional genome: Principles and roles of long-distance interactions

M. Jordan Rowley, Victor G. Corces

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations


The linear sequence of eukaryotic genomes is arranged in a specific manner within the three-dimensional nuclear space. Interactions between distant sites partition the genome into domains of highly associating chromatin. Interaction domains are found in many organisms, but their properties and the principles governing their establishment vary between different species. Topologically associating domains (TADs) extending over large genomic regions are found in mammals and Drosophila melanogaster, whereas other types of contact domains exist in lower eukaryotes. Here we review recent studies that explore the mechanisms by which long distance chromatin interactions determine the 3D organization of the genome and the relationship between this organization and the establishment of specific patterns of gene expression.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalCurrent Opinion in Cell Biology
StatePublished - Jun 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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